The U.S. Coast Guard will establish a temporary security zone Wednesday to Friday in designated waters of the Choptank River for the Republican Issues Conference. The security zone will be in effect from 3 a.m. Wednesday until 1 p.m. Friday, which may limit or prohibit navigation by commercial and recreational waterway users. The security zone will include a 500-yard perimeter surrounding the waterfront of the Hyatt Regency Hotel on the Choptank River in Cambridge. The security zone will also impact waterway traffic under the Route 50 Bridge for various periods of time. Entering or operating in the security zone is prohibited unless authorized by the captain of the port of Coast Guard Sector Baltimore.